In conclusion, our study explored the molecular mechanism of Ox-LDL-induced atherosclerosis in vitro and found that immune intervention with specific Ox-ApoB fragments can largely protect the endothelial cell connection barrier and thus prevents the apoptosis and necrosis of arterial endothelial cells caused by the stimulation of Ox-LDL and ultimately inhibits the progression of atherosclerosis. This evidence concerns the gene APOB and atherosclerosis.