These results indicate that DCN activates AMPK to inhibit mTOR and promotes autophagy in AMPK-dependent manner in ARPE-19 cells, in line with previous studies that observed DCN evoked autophagy by regulating AMPK-mTOR signaling in endothelial, nucleus pulposus, and glioma cells [22, 39, 46]. The gene discussed is MTOR; the disease is central nervous system cancer.