However, later research on these phosphatases showed that upregulation of Spry1 or Spry2 is essential for providing a positive feedback loop on ERK1/2 activity and silencing of these proteins resulted in tumor regression (Schaaf et al., 2010[46]) including in BRAF-mutated melanomas (Montico et al., 2020[40]). Here, MAPK3 is linked to neoplasm.