Table 7 cataloged the top 20 keywords with the strongest citation bursts. The top five hotspots were: pulmonary surfactant (11.69), respiratory distress syndrome (9.53), congenital alveolar proteinosis (6.38), surfactant protein b (5.95), deficient mice (5.23). Subsequently, keywords such as “inflammation,” “deficiency,” “tissue resident macrophage,” “classification,” “autoimmune pulmonary alveolar proteinosis,” “sarcoidosis,” “gm csf,” “high-resolution ct,” and “fetal monocyte” appeared frequently in the last 5 years (Table 8). The gene discussed is SFTPB; the disease is newborn respiratory distress syndrome.