Hibiscus sabdariffa leaf polyphenolic extract, a flavonoid-rich extract, has been shown to prevent foam cell formation and intracellular lipid accumulation in oxidised-LDL (ox-LDL)-induced macrophages and increased Liver X receptor alpha (LXRα)/ABCA1 activity, which inhibited atherosclerosis and stimulated cholesterol removal from macrophages (Leng et al., 2018). Here, NR1H3 is linked to atherosclerosis.