LDLR and thyroid tumor: In addition, the increased cholesterol concentrations promoted the pro-inflammatory state induced by LPS/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).Revilla et al. (2019) found that LDLR expression was up-regulated in more aggressive thyroid tumour cells, while HMGCR expression was down-regulated, increasing cellular cholesterol concentration.Huang et al. (2021) found that high expression of LDLR was associated with poor prognosis in patients with ovarian cancer, whereas high expression of HMGCR was associated with better outcomes.