Statins were demonstrated to selectively lower cholesterol in hepatoma cells, inducing p53-dependent apoptosis in cancer cells, sparing the primary hepatocytes (Kah et al., 2012).Kah et al. (2012) demonstrated that potent knockdown of the wild-type p53 in Huh7 cells, which is overexpressed, restored the cells’ sensitivity to statin-induced toxicity. This evidence concerns the gene TP53 and cancer.