TP53 and cancer: Furthermore, a wide range of phytochemicals such as crocetin (Ray et al., 2016), quercetin (Yang et al., 2016), curcumin (Yang et al., 2018), gallic acid (Watson et al., 2010), hispidin (Lim et al., 2014) and capsaicin (Jin et al., 2014) have also shown a potential as possible anticancer agents that can be used to restore p53 function in cancer cells.