In addition, the Cyp2b-null males develop nonalcoholic steatohepatitis (NASH) after treatment with a choline-deficient amino acid defined high-fat diet methionine-choline-deficient (CDAHFD) diet probably because of increased NAFLD compared to WT mice [31]. This evidence concerns the gene CYP2B6 and metabolic dysfunction-associated steatotic liver disease.