In addition to findings in animal models, autopsy findings revealed that GPX4 was downregulated and arachidonate 12/15-lipoxygenase (ALOX15) was upregulated, and the enhanced lipid peroxidation was observed, evidenced by elevated 4-hydroxynonenal (4-HNE) in the brains of AD patients (Yoo et al., 2010). Here, GPX4 is linked to Alzheimer disease.