Screening a large number of children with AARD and related conditions, Schmeling et al. identified a remarkable increase in frequency of anti-DFS70 antibodies in children with juvenile localized scleroderma (13.8%, 4/29), in patients with juvenile DM (18.2%, 2/11) and in those with uveitis (11.5%, 3/26) (27). This evidence concerns the gene PSIP1 and localized scleroderma.