In contrast to other ANAs, among adults there is no association between monospecific (i.e., without detection of other ANA-specific antibodies) anti-DFS70 antibodies and ANA-associated rheumatic diseases (AARD), such as systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjögren syndrome, systemic sclerosis (SSc) or dermato-/polymyositis (DM/PM) (18–21). The gene discussed is PSIP1; the disease is rheumatic disorder.