We then tested the performance of CRP, IL-6, and IL-10 to predict bacterial infection; the AUCs of CRP, IL-6, and IL-10 were 0.614 (95% CI, 0.531–0.697), 0.703 (95% CI, 0.626–0.780) (Figure 5A), and 0.657 (95% CI, 0.577–0.737), indicating IL-6 was the most powerful biomarker to predict bacterial infection. Here, CRP is linked to bacterial infectious disease.