Women with a family history of multiple malignancies, especially breast and ovarian carcinoma, are offered genetic counseling, and in some cases, testing is triggered by the identification of a family member with PVs in BRCA1/2. When a woman is identified as a carrier, she is made aware of the significance of the results, namely, the risk of developing various malignancies, the potential preventive treatment options available, and recommended follow-up algorithms. The gene discussed is BRCA1; the disease is ovarian carcinoma.