RNF2 and cardiac hypertrophy: To clarify which gene plays a key role in the elderly hypertrophic cardiomyopathy, we conducted correlation analysis using 12 months and 18 months mouse heart RNA sequencing count data from the GSE161078 dataset and found that Bmi‐1 and Rnf2 (RING1B) were negatively related to the marker genes of aging, cardiac hypertrophy and inflammation (Figure 1C).