The SIRT1 gene is associated with lung Injury, autoimmune diseases, liver cirrhosis, HIV infections, diabetes, heart diseases while the MED17, BIRC3 and ETS1 are respectively linked with 20, 19 and 3 diseases including infiltrate of lung, anemia, liver cirrhosis, fever, reperfusion injury, hypsarrhythmia, especially which could be a severe comorbidities for the SARS-COV-2 patients. This evidence concerns the gene SIRT1 and heart disorder.