Because of the high negative predictive value of CCTA for CAD risk stratification (16), we examined 2 potentially novel lipoprotein-related tests that could be implemented for routine testing, namely ApoE-containing HDL-C (ApoE-HDL-C) and the content of ApoC-III in HDL, for their association with CAC and CCTA. This evidence concerns the gene APOC3 and coronary artery disorder.