Interestingly, plasma samples from breakthrough VRs inhibited binding of ACE2 to all 5 spike proteins to a degree that was similar to the level seen with plasma obtained from postboost VRs at the 1- to 3-month time point, indicating that infection with the Omicron variant did not enhance ACE2-inhibiting antibodies (Figure 2D). The gene discussed is ACE2; the disease is infection.