To illustrate the role of ZIP8 in AEC2 renewal and lung fibrosis in vivo, we generated a mouse line with targeted deletion of Slc39a8 in the adult AEC2 compartment — SFTPC-CreER Rosa26-tdTomato Zip8fl/fl (Zip8AEC2) — by crossbreeding Slc39a8-floxed mice with SFTPC-CreER Rosa26-tdTomato mice. The gene discussed is SLC39A8; the disease is pulmonary fibrosis.