LRP1B and hepatocellular carcinoma: GSEA enrichment analysis showed that HCC samples with high LRP1B expression were significantly enriched in endoplasmic reticulum-related pathways, such as COPI Dependent Golgi to ER Retrograde Traffic, ER to Golgi Anterograde Transport and Golgi to ER Retrograde Transport (all normalized p-value < 0.05) (Figure 6a).