In vivo, BTZ exerted limited inhibitory effect on NSD2(S56D)‐LP‐1 cells derived tumours, but exhibited marvellous anti‐MM growth effect on the NSD2(S56A)‐LP‐1 cells derived tumours, when compared to the wild type NSD2 (NSD2(WT)‐LP‐1) derived tumours (Figure 4L), and the overall survival was significantly improved only in mice bearing NSD2(S56A)‐LP‐1 cells derived tumours (p < .001) (Figure 4M). Here, CASC3 is linked to neoplasm.