It is a remarkable fact that some highly decreased genes, such as IL6R, ERBB3, LRP1, STC2, SULF2, GAA, ZNF467, SLC37A1, AIG1, TCEA2, TXNDC5 and GNG7 were cancer drug–resistance related, of which qPCR results validated that LRP1, STC2, AIG1, TCEA2, GNG7 and IL6R all augmented in the BR MM cells (Figure 6D). The gene discussed is TXNDC5; the disease is cancer.