Since NSD2 exerts its function mainly through methyltransferase activity, we examined whether dimethylation  at histone 3 lysine 36 (H3K36me2) could be affected by Aurora A. Indeed, we found that methyltransferase activity of NSD2 was altered by Aurora A expression accordingly, as H3K36me2 level obviously augmented in Aurora A‐OE MM cells, and remarkably suppressed in Aurora A‐KO MM cells, respectively (Figure 3G,H). This evidence concerns the gene NSD2 and Miyoshi myopathy.