As a consequence, t(4;14) translocation renders an extra expression of multiple myeloma SET domain containing protein (MMSET, also named WHSC1/NSD2) in all patients, and the fibroblast growth factor receptor 3 (FGFR3) in about 70% patients, of which only MMSET has been proved to be essential to the pathogenesis of MM.9, 10. This evidence concerns the gene NSD2 and Miyoshi myopathy.