NSD2 and Miyoshi myopathy: As to the mechanism of Aurora A overexpression in t(4:14) positive MM cells, we speculate that Aurora A level is regulated mainly at posttranslational level by NSD2, but we can't exclude other factors affecting overexpression of Aurora A. By immunoprecipitation of NSD2 protein and mass spectrum assay, we identified that the direct interaction between Aurora A and NSD2 could achieve the phosphorylation of NSD2 at serine 56 residue, and consequently improve its methyltransferase activity.