It is a serious complication of diabetes caused by a decrease1 in effective circulating insulin and elevations in counter-regulatory hormones, often leading to hyperglycemia, ketone body formation, osmotic diuresis, acid-base and electrolyte derangements, and hypovolemia.1,2,3,4 The tenets of management of DKA are the administration of insulin and the correction of the fluid and electrolyte abnormalities. The gene discussed is INS; the disease is Hyperglycemia.