Accordingly, the increase in OxPhos induced by β-glucan training was abolished by Set7 inhibition.116 This crucial role of Set7 early in the induction of trained immunity is consistent with its role as an epigenetic writer of metabolic memory in cultured vascular endothelial cells133,134 and peripheral blood mononuclear cells from patients with type 2 diabetes mellitus (T2DM).135. Here, SETD7 is linked to diabetes mellitus.