Indeed, strategies to inhibit glutaminolysis have proven effective in slowing the proliferation of cancer cells.74 Addiction to glutamine is a prominent feature of Kirsten rat sarcoma virus, oncogene (KRAS)-mutant cancers.75,76 A recent study showed that mutant KRAS rewires glutamine metabolism to support succinate biosynthesis from α-KG in colorectal cancer cells, resulting in an overall reduction of 5 hmc and CpG hypermethylation, and the activation of Wingless-related integration site/β-catenin signalling.77 The gene discussed is KRAS; the disease is cancer.