CRHR1 and Anxiety: For example, pharmacological blockade of CeA CRF1 attenuates stress-induced increases in anxiety-like behavior (Henry et al., 2006), nociception (Itoga et al., 2016), and alcohol drinking (Roberto et al., 2010; Weera et al., 2020), as well as fear acquisition and expression (Sanford et al., 2017).