FGF1 and neoplasm: We have shown that engineeredvariants of FGF1 conjugated with MMAE as well as FGF2-MMAE and FGF2-AY(auristatin Y) conjugates induce a cytotoxic effect in vitro, specificallyin cells overexpressing FGFR1.43,64,65 We have also shown in a mouse model that FGF2 conjugated with PEGylatedMMAE inhibits the growth of the tumor overexpressing FGFR1.44