The specific binding of its target ligand EMI-137 was confirmed with in vitro studies, which showed cytoplasmatic accumulation of EMI-137 in the MET-positive PTC cell line (TPC1; Fig. 2c), whereas no EMI-137 binding was observed in the MET-negative breast cancer cell line (T-47D; Fig. 2d). The gene discussed is MET; the disease is breast carcinoma.