HMGA2 is involved in the tumorigenesis and progression of different malignancies, included but not limited to lung cancer, breast cancer, acute myeloid leukemia, ovarian cancer, clear cell renal cell carcinoma, head and neck cancer, hepatocellular carcinoma, pancreatic cancer, and gastric cancer.15, 16, 17, 18, 19, 20. The gene discussed is HMGA2; the disease is familial pancreatic carcinoma.