The expression of hepatic marker genes, such as ALB, AFP, A1AT and Cp, was decreased by the addition of a high concentration (200 μM) of oleic acid in WD-specific hepatocytes but not in WTC11-derived hepatocytes (Supplementary Material, Fig. S7D and E), suggesting that the WD-specific hepatocytes being more susceptible to the effect of oleic acid than WTC11-derived ones. This evidence concerns the gene SERPINA1 and Wilson disease.