Following myocardial infarction, SGLT2 inhibitors increase cardiac M2 macrophage numbers and levels of IL-10, a potent anti-inflammatory cytokine.373 Serum levels of IL-10 also increase following dapagliflozin treatment in T2DM patients.374 In addition to the immune response, evidence also points to an effect of SGLT2 inhibitors on the autonomic nervous system. The gene discussed is SLC5A2; the disease is myocardial infarction.