HSPB6 and diabetes mellitus: In the light of these findings, the cargo of EVs could potentially be engineered to deliver beneficial biomolecules as a new avenue for treating diabetes complications.289,293 Indeed, using streptozotocin-induced diabetic mice with cardiac-specific overexpression of Hsp20, Wang et al. 294 have demonstrated that cardiomyocyte-specific EVs carrying overexpressed Hsp20 beneficially attenuate streptozotocin-induced cardiac dysfunction and adverse remodelling.