IL10 and type 2 diabetes mellitus: Following myocardial infarction, SGLT2 inhibitors increase cardiac M2 macrophage numbers and levels of IL-10, a potent anti-inflammatory cytokine.373 Serum levels of IL-10 also increase following dapagliflozin treatment in T2DM patients.374 In addition to the immune response, evidence also points to an effect of SGLT2 inhibitors on the autonomic nervous system.