ACE and major depressive disorder: Experimental data suggest that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may have a protective effect against depression in older individuals via anti-inflammatory and direct neuroprotective effects, and via beneficial effects on the brain vasculature (Culman et al., 2002; Saavedra et al., 2011; Vian et al., 2017).