The Nrf2 signaling pathway [55], mTOR signaling pathway [56], TGF-β1 signaling pathway [57], and NF-κB signaling pathway [56] may be interfered by Rg1, and target myocardial cells, podocytes, thereby preventing renal fibrosis [55], nerve ischemia perfusion injury [56], and lung fibrosis [57]. The gene discussed is NFKB1; the disease is renal fibrosis.