CASP3 and herpes simplex infectious disease: Then, they were input into the STRING database to obtain the PPI network, and the top hub proteins (CXCL8, IL-12, IFN-γ, MAPK1, JUN, EGFR, PTGS2, CASP3, MAPK8, MYC, TP53, AKT1, and MMP9) were identified (Figure 5(b)), which might play roles in the treatment of herpes simplex by astragalus.