In our study, it was found that the costimulation of APS and HSV-1 in mice could significantly increase the production of local CD8+ TRM cells, inhibit pathological changes, and enhance the immunity within only 8 days, enlightening us that APS might be effective for preventing infections caused by other viruses, such as human papillomavirus (HPV), which needs to be further explored by much more experiments in the future. The gene discussed is CD8A; the disease is infection.