The genistein and myricetin cause prevention of obesity by elevation of UCP-1 expression, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), and PRDM-16 which promotes brown adipogenesis through PPAR-gamma as shown in Figure 3 [84]. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.