•AVP-neurophysin II gene alterations•Wolfram (DIDMOAD) syndrome•Septo-optic dysplasia•Schinzel-Giedion syndrome•Culler-Jones syndrome•Alstrom syndrome•Hartsfield syndrome•Webb-Dattani syndrome•X-linked defects with subnormal AVP levels. The gene discussed is AVP; the disease is Hartsfield-Bixler-Demyer syndrome.