POMC and Central hypothyroidism: When DI derives from an injury to the hypothalamus-pituitary (CDI), it may be accompanied by deficiency of anterior pituitary hormones such as adrenocorticotropic hormone (ACTH), resulting in adrenal insufficiency, TSH in central hypothyroidism, gonadotropins in hypogonadism, and deficit of growth hormone and prolactin (3, 44).