The expression of TIPE2 was negatively associated with lymph node metastasis (p = 0.004) and disease progression (p = 0.021), while age, gender, recurrence status, smoking condition, tumor T stage, vascular invasion, nerve invasion and pathological grade did not differ significantly between patients with negative/low and high TIPE2 expression. The gene discussed is TIPE2; the disease is metastatic malignant neoplasm in the lymph nodes.