Knockdown of Snail in HUVECs offset the effect of NPC43 exosomes on cellular morphology (Fig. 4B), reduced TJ protein expression, increased mesenchymal cell marker expression (Fig. 4C), and promote the traversal of rhodamine-labeled dextran (Fig. 4D) and the transendothelial invasion of cancer cells (Fig. 4E). Here, SNAI1 is linked to cancer.