HMGA2 and nasopharyngeal carcinoma: The results showed that only overexpression of HMGA2 can switch the morphology of endothelial cells from pebble-shaped to spindle-shaped (Supplementary Fig. S6C) and increase vascular permeability (Supplementary Fig. S6D), indicating that HMGA2 may account for endothelial cell functional changes induced by exosomes derived from EBV-positive NPC cells.