EBV drives NPC metastasis through EBV-encoded LMP1-mediated metabolic reprogramming via activation of IGF1-mTORC2 signaling and nuclear acetylation of the Snail promoter by PDHE1α [20], LMP1 upregulates calreticulin to induce EMT via the TGF-β/Smad3/NRP1 pathway in nasopharyngeal carcinoma cells [21]. This evidence concerns the gene SMAD3 and nasopharyngeal carcinoma.