Among these proteins, HMGA2, CEMIP, DDX6, MTA2 and CD82 emerged as prominent proteins in exosomes from all three EBV-positive NPC cell lines and had low or undetectable expression in exosomes from seven EBV-negative NPC cell lines (Fig. 3A and Supplementary Fig. S6A), suggesting a specific association with vascular destruction potential and EndMT. The gene discussed is MTA2; the disease is nasopharyngeal carcinoma.