We found that exosomal HMGA2 derived from EBV-positive NPC cells can be internalized by endothelial cells with low HMGA2 expression and subsequently promote endothelial cell permeability and EndMT, which means that HMGA2 has function in enhancing tumor cell invasion (of tumor cells themselves) and weakening endothelial barriers (the tumor microenvironment). The gene discussed is HMGA2; the disease is nasopharyngeal carcinoma.