We assessed the NPS and other possible prognostic factors (age, gender, smoking, drinking, COPD, family history of cancer, BMI, TNM stage, histology, lesion, laterality, surgery, chemotherapy, radiotherapy, targeted therapy, CEA, NSE, albumin, total cholesterol, NLR, LMR, PNI, CONUT and SIS), to predict the OS and PFS of NSCLC patients in present study. This evidence concerns the gene ENO2 and non-small cell lung carcinoma.