Initially considered as an inflammatory disease, cytogenetic studies revealed that PVNS is associated with a chromosomal translocation: t (1; 2) (p13; q35) that fuses COL6A3 (encoding collagen type VI α3) to colony-stimulating factor 1 (CSF-1), and also revealed that PVNS is a neoplasm that can exhibit destructive behavior3. Here, CSF1 is linked to neoplasm.