HLA-DRB1 and type 1 diabetes mellitus: In particular, HLA-DRB1*04:01 (DR0401), DQA1*03:01-DQB1*0302 (DQ8), HLA-DRB1*03:01 (DR0301) and DQA1*05:01-DQB1*02:01 (DQ2), confer high risk with about 80-90% of T1D patients carrying at least one of these risk alleles25.