IL15 and neoplasm: To further enhance IL-15 activity, Kowalsky et al. recently engineered oncolytic VV to express a superagoinst IL-15 (a fusion protein of IL-15 and IL-15Rα) and named it vvDD-IL15-Rα.232 As a result, vvDD-IL15-Rα induced strong antitumor activity and prolonged the survival time of tumor-bearing mice.