An engineered OV generated from VSV encoding IFNγ demonstrated greater activation of DCs and induced greater secretion of proinflammatory cytokines than the parental virus and showed pronounced antitumor effects in several murine tumor models.241 OAd armed with IFNγ (CNHK300-hIFN-γ) showed antitumor effects through triplex mechanisms, including selective oncolysis, antiangiogenic effects, and immune responses.242. The gene discussed is IFNG; the disease is neoplasm.