Dysregulation of miRNAs contributes to tumor progression, invasion, angiogenesis and metastasis in many types of cancers.121 miRNAs have been categorized into two classes according to their altered expression in tumor cells: oncogenic miRNA upregulation promotes tumorigenesis by blocking the translation of tumor suppressor protein mRNAs, and tumor suppressor miRNA downregulation generally suppresses the translation of oncoprotein mRNAs.122 Hence, elevating tumor suppressor miRNA levels or inhibiting oncogenic miRNA expression is a promising potential therapeutic approach. This evidence concerns the gene TCHP and neoplasm.