The deletion of the E1A and E1B 55K genes make the AdV selectively replicate in retinoblastoma (pRb)- and p53-mutated tumor cells.31 The partial deletion in the E3 region allows AdV to encode immunostimulatory transgenes, which can enhance antitumor immunity.32 The Arg-Gly-Asp (RGD) motif was inserted into the HI loop of the AdV fiber protein to improve the infectivity of AdV.33 This evidence concerns the gene DHTKD1 and neoplasm.