This antitumor efficacy was associated with marked IL-12 and IFN-γ expression, which induced an increase in the number of CD4+ and CD8+ lymphocytes in the TME.207 oHSV-IL-12 elicited local and systemic immune responses, completely preventing the growth of distant untreated lung tumors in mice.208 Scientists have also tested the antitumor efficacy of oHSV-IL-12 in ovarian carcinomas,209 glioblastoma,210–212 neuroblastoma,213,214 colorectal cancer215 and prostate cancer.216 oHSV-IL-12 showed enhanced antitumor efficacy that is mainly mediated by T-cell immune responses. Here, CD8A is linked to glioblastoma.