Although we cannot exclude the possibility that HspBp1-induced tumor suppression is mediated by other interacting partners such as Hsp70, which plays a critical role in cancer initiation and progression [37], it is tempting to speculate that the positive impact of HspBP1 on BRCA1 functioning is related to anti- tumorigenesis in breast cancer. Here, HSPBP1 is linked to breast cancer.