CD274 and neoplasm: We have shown here that the hydrogel could act as a local reservoir to provide sustained releases of PLX-NP and P-aPD-1 for the enhanced efficacy of tumor immunotherapy by depleting TAMs to facilitate T cell infiltration and in situ promoting aPD-1 release in a bioresponsive manner for blocking the PD-1/PD-L1 pathway to re-activate infiltrated T cells.