CD8A and neoplasm: In addition, a significantly increased number of CD8+ T cells in the tumor tissues treated with all aPD-1 formulations were observed compared with other treatment groups, while the highest density of CD8+ T cells in the tumor tissue was achieved in the PLX-NP-P-aPD-1@Gel group, which was 2-fold higher than that in the P-aPD-1@Gel group, highlighting that the TAM depletion by PLX-NP contributed substantially to the enhanced infiltration of CD8+ T cells (Fig. 4d).