In summary, the 35 subjects included in the molecular analysis of the SLC2A5 gene presented (I) clinically relevant symptoms that are consistent with acquired fructose-malabsorption, (II) demonstrated abnormal fructose-induced breath test and (III) relevant other related diagnoses (e.g. coeliac disease, hereditary fructose intolerance) were basically excluded. This evidence concerns the gene SLC2A5 and hereditary fructose intolerance.