GZFL could inhibit acetaldehyde‐induced cellular fibrosis and alleviate CCL4‐induced liver fibrosis by inhibiting TGF-β1/Smad2/3, CUGBP1 signaling and activating IFN-γ/STAT1/Smad7 signaling. The gene discussed is TGFB1; the disease is Hepatic fibrosis.