The lead SNP rs2954021 (P=4.6×10−14) located upstream of the pleiotropic TRIB1 gene has been associated with various metabolic traits, liver enzymes, plasma lipids, kidney function, blood cell traits, hepatic steatosis, and coronary heart disease (Figure S18 shows examples of colocalization of the ACE2 associations with high-density lipoprotein, low-density lipoprotein, BMI, and waist circumference). This evidence concerns the gene ACE2 and coronary artery disorder.