Next, to examine the shared genetic basis between plasma ACE2 level and specific vascular diseases or diagnoses, we specifically extracted the GWAS summary-level data for 48 vascular disease–related phenotypes from UK Biobank (see Methods and Table S10), categorized into 18 for heart disease, 15 for blood pressure, 9 for stroke, and the other 6 for blood lipids. This evidence concerns the gene ACE2 and heart disorder.