ACE2 and COVID-19: As validation, in the Host Genetics Initiative COVID-19 hospitalization data (GWAS B2, GenOMICC subtracted), we estimated the causal effect of ACE2 with an odds ratio of 1.52 (95% CI, 1.05–2.21; P=0.03), and in the Host Genetics Initiative COVID-19 infection data (GWAS C2, GenOMICC subtracted), the estimated odds ratio was 1.60 (95% CI, 1.08–2.37; P=0.02).