The chromosome 14 locus (EXOC3L4 intronic lead variant rs2274685, P=3.7×10−16) has been associated with liver enzymes, platelet quantitative traits, and gene expression of CDC42BPB, whereas another nearby gene, TNFAIP2, is abundantly expressed in immune cells and has been implicated in inflammation and infectious disease.41 From conditional and joint multi-SNP analyses of these discovered loci, we identified a secondary genome-wide significant association at the EXOC3L4 locus on chromosome 14 (lead variant rs73356643, GWAS P=1.3×10−6, conditional P=1.0×10−8). Here, CDC42BPB is linked to infectious disease.