Higher ACE2 has additionally been associated with poorer prognosis in patients with preexisting CVD and recently was found to prospectively predict incident CVD, mortality, diabetes, and heart failure in previously unaffected individuals,9–12 independently of traditional risk factors.45 In particular, ACE2 was ranked higher as a predictor of overall mortality compared with smoking, diabetes, blood pressure, BMI, and lipids. Here, ACE2 is linked to heart failure.