In population-based genetic studies, rs28929474 has been associated with various metabolic phenotypes (height, bone mineral density, systolic blood pressure, fat-free mass, gallstones, lipids), pulmonary function, alcohol consumption, and plasma levels of various hepatic enzymes (alkaline phosphatase, alanine aminotransferase) and acute-phase proteins synthesized in the liver (eg, CRP, AFP). The gene discussed is CRP; the disease is gallstones.