Both of these HNF1A and HNF4A missense variants have previously been associated with high-density lipoprotein, low-density lipoprotein, total cholesterol, type 2 diabetes, coronary heart disease, C-reactive protein (CRP), fibrinogen, coagulation factor VII, and other hepatically synthesized enzymes or enzyme inhibitors such as γ-glutamyl transferase or α1-antitrypsin levels. This evidence concerns the gene CRP and type 2 diabetes mellitus.