ACE2 and COVID-19: Here, by performing so far the largest genome-wide association meta-analysis of plasma ACE2 (n=28 204), we summarize the cross-sectional epidemiological correlates of circulating ACE2; report 10 pQTL, including 8 novel for ACE2; estimate relevant genetic correlations with other cardiometabolic phenotypes; and conduct causal inference of soluble ACE2 on vascular disease outcomes and COVID-19 severity using mendelian randomization (MR).