These findings have potential therapeutic implications for the counterregulatory ACE2/angiotensin-(1–7) axis in modulating COVID-19 severity.55 In particular, identification of additional genetic factors involved in the regulation of ACE2 levels may help disentangle the potential causal roles of soluble versus cellular ACE2 in the regulation of chronic diseases, COVID-19 infection, disease severity, and immunity. The gene discussed is ACE2; the disease is COVID-19.