A recent genome-wide analysis of soluble ACE2 measured in plasma of 3442 patients with heart failure identified 3 genome-wide significant protein quantitative trait loci (pQTL): a cis-pQTL on chromosome X (located near the cognate ACE2 gene) and 2 trans-loci on chromosomes 12 and 21 encompassing the genes encoding transcription factors HNF1A and ERG, respectively.15 Current antibody-based ACE2 pQTL studies have been insufficient to capture enough heritability of the protein or to estimate downstream genetic connections between ACE2 and diseases such as CVD and COVID-19. This evidence concerns the gene ACE2 and COVID-19.