While the HAMP variant has been described at the origin of an out of frame uoORF in (15) and described by Matthes and collaborators (17) as potentially generating an abnormal protein responsible for juvenile hereditary hemochromatosis, we did not find any stop codon in the transcript NM_021175.4 sequence that could be in frame with this created uAUG. This evidence concerns the gene HAMP and hemochromatosis type 1.