Another statin, mevastatin, in combination with histone deacetylase inhibitors increase its anti-cancer effects by blockade of the autophagy flux mediated by preventing Vps34/Beclin1 complex formation and downregulating prenylated Rab7, a small GTPase necessary for the autophagosome-lysosome fusion (Lin et al., 2017). Here, PIK3C3 is linked to cancer.