The expression of C5AR1 was significantly increased in MCAO- and OGD-induced modela, and inhibition of C5AR1 by its inhibitors such as DF3016A and PMX53 exhibited a remarkable neuroprotective effect and caused an obvious inhibition in neuro-inflammation and cell apoptosis in primary cortical neurons and a MCAO-induced stroke model (Shi et al., 2017; Brandolini et al., 2019). The gene discussed is C5AR1; the disease is Stroke.