Elevated sera TNFR1 and TNFR2 were associated with reduced total filtration surface per glomerulus, podocyte number per glomerulus, filtration slit frequency, fenestrated endothelium, and increased glomerular basement membrane width, foot process width, mesangial fractional volume, and global glomerular sclerosis in diabetic patients with early nephropathy (Pavkov et al., 2016). This evidence concerns the gene TNFRSF1B and kidney disorder.