This is the first time we have observed such an intense and copious amount of STAT3 activation in a mouse model of RP as, in the rhodopsin mouse models, the pSTAT3-Tyr705 labeling was confined or mostly confined to the Müller cells and photoreceptors; however, as observed in the BXD32 retina, the STAT3 activation broadens to nearly every retinal cell type as early as p63 with a concomitant propagation across the entire retinal section by p147. Here, RPE65 is linked to retinitis pigmentosa 1.