EDN1 and chronic kidney disease: Previous in vivo study showed that TGT can up-regulate the level of NO, down-regulate the levels of serum endothelin-1 (ET-1) and angiotensin-II (AngII), and lower TNF-α, IL-6, transforming growth factor- (TGF-) β1 levels to improve the vascular endothelial injury of CKD rats (Xu et al., 2021).