Through the Akt serine/threonine kinase (Akt)-endothelial nitric oxide synthase (eNOS) signaling pathway, S. miltiorrhiza and ligustrazine injection (SLI) show a good impact on myocardial ischemia/reperfusion (I/R) and hypoxia/reoxygenation (H/R) damage in mice exposed to coronary artery occlusion (Huang et al., 2016). The gene discussed is NOS3; the disease is myocardial ischemia.