Among these DEGs, 13 hub genes were demonstrated to be associated with the poor prognosis of gliomas, including PBK, KIF2C, CENPE, KIF14, MND1, FAM83D, NEIL3, CDKN3, F5, IGFBP5, TNC, SCG3, and IGFBP3. This evidence concerns the gene PBK and central nervous system cancer.