Also, we observed 13 hub genes were related to the poor prognosis of gliomas, including PBK, KIF2C, CENPE, KIF14, MND1, FAM83D, NEIL3, CDKN3, F5, IGFBP5, TNC, SCG3, and IGFBP3. This evidence concerns the gene SACK1D and central nervous system cancer.