IGFBP5 and central nervous system cancer: Among these DEGs, 13 hub genes were demonstrated to be associated with the poor prognosis of gliomas, including PBK, KIF2C, CENPE, KIF14, MND1, FAM83D, NEIL3, CDKN3, F5, IGFBP5, TNC, SCG3, and IGFBP3.