MTHFR and metabolic syndrome: In this context, Massa et al. (48) investigated the effect of a watermelon extract (Citrullus lanatus) supplementation (6 g/day) in adults carriers of MTHFR rsC677T or rs1801133 with diagnosed with dyslipidemia and found that total cholesterol and LDL-c levels were reduced after 6 weeks (p < 0.01).