Subjects with T2D, carriers ofCD36-G PPARG-G and NOS3-A allele tended to respond better ton-3 fatty acids in improving lipid profiles (TG, LDL-c, and LDL-c TC, respectively) This interaction is mainly attributed to the fish oil supplements (2 g/day of C20:5n-3 and C22:6n-3). This evidence concerns the gene NOS3 and type 2 diabetes mellitus.